Here we develop advanced computational analysis methods – intersecting medical image analysis, cardiovascular imaging and fluid dynamics– for advanced quantification & visualization of 3D time-resolved intra-cardiac hemodynamics from the state-of-the-art 4D Flow MRI technology. These techniques are aimed at enabling objective non-invasive assessment of the complex intra-cardiac hemodynamics including blood flow patterns (e.g. vortex flow) and energetics (e.g. energy loss and kinetic energy) to improve diagnosis and treatment of heart disease. Current projects include assessment of advanced hemodynamics in congenital heart disease (e.g. Fontan, tetralogy of Fallot, atrioventricular septal defect) and acquired heart disease (pulmonary hypertension, mitral regurgitation, atrial fibrillation, hypertrophic cardiomyopathy, heart failure) for deriving better diagnostic hemodynamic markers and outcome prediction.
Selected Publications (Full list can be found here: ORCID Google Scholar Pubmed)
- Mohammed SM Elbaz, Emmeline E Calkoen, Jos JM Westenberg, Boudewijn PF Lelieveldt, Arno AW Roest, Rob J van der Geest: Vortex flow during early and late left ventricular filling in normal subjects: quantitative characterization using retrospectively-gated 4d flow cardiovascular magnetic resonance and 3 dimensional vortex core analysis. Journal of Cardiovascular Magnetic Resonance 2014 16:78.
- Elbaz, M. S., van der Geest, R. J., Calkoen, E. E., de Roos, A., Lelieveldt, B. P., Roest, A. A., & Westenberg, J. J. (2017). Assessment of viscous energy loss and the association with three‐dimensional vortex ring formation in left ventricular inflow: In vivo evaluation using four‐dimensional flow MRI. Magnetic resonance in medicine, 77(2), 794-805.
- Elbaz, Mohammed SM, Boudewijn PF Lelieveldt, and Rob J. van der Geest. “Hierarchical Shape Distributions for Automatic Identification of 3D Diastolic Vortex Rings from 4D Flow MRI.” Medical Image Computing and Computer-Assisted Intervention–MICCAI 2015. Springer International Publishing, 2015. 467-475.
- Kamphuis V*, Elbaz MS*, van den Boogaard PJ, Kroft LJ, van der Geest RJ, de Roos A, Helbing WA, Blom NA, Westenberg JJ and Roest AA. Disproportionate Intraventricular Viscous Energy Loss in Fontan Patients: analysis by 4D Flow MRI. European Heart Journal–Cardiovascular Imaging. 2018; (* shared first-author).
- Kamphuis, Vivian P., Jos JM Westenberg, Roel LF van der Palen, Pieter J. van den Boogaard, Rob J. van der Geest, Albert de Roos, Nico A. Blom, Arno AW Roest, and Mohammed SM Elbaz. (2018) “Scan–rescan reproducibility of diastolic left ventricular kinetic energy, viscous energy loss and vorticity assessment using 4D flow MRI: analysis in healthy subjects.” The international journal of cardiovascular imaging: 1-16.
- Liang Zhong, Eric Schrauben, Julio Garcia Flores, Sergio Uribe, Stuart Grieve, Mohammed S. M. Elbaz, Alex Barker, Julia Geiger, Sarah Nordmeyer, Alison Marsden, Marcus Carlsson, Ru-San Tan, Pankaj Garg; Jos Westenberg, Michael Markl, Tino Ebbers “Intracardiac 4D flow MRI in congenital heart disease: Recommendations on behalf of the ISMRM Flow & Motion Study Group”. Journal of Magnetic Resonance Imaging 2019
- Trung Bao Le, S.M. Elbaz, Rob J. Van der Geest and Fotis Sotiropoulos, Qualitative and quantitative cross-evaluations of left ventricular hemodynamics in a healthy subject: image-guided simulation and four-dimensional MRI data. Flow, Turbulence and Combustion. 2019