Left Ventricular (LV) strain is generally reported as a global measure (averaged across the entire ventricle) due to its high reproducibility. Strain can be calculated at a more regional level as well, generally based on the 16 segments of the LV outlined by the AHA, but this type of segmental strain is not used clinically due to its lower reproducibility. However, regional strain measurements have the potential of being important localized biomarkers to track cardiac disease and responses to treatment. The workflow to obtain segmental strain is depicted below in Figure 1.
There is limited work done on assessing the reproducibility of strain measured at individual LV segments. Therefore, the goal of this project is to understand strain reproducibility at each LV segment to determine if any can be introduced for use in the clinical setting. The secondary goal is to create an optimized model of the heart to improve reproducibility while maximizing the geographical specificity of strain measurements.
Publications accepted on this work:
- Siva Sreedhar, Aakash Gupta, Teodora Chitiboi, Maurice Pradella, Mohammed S.M. Elbaz. “Left Atrial Circumferential Strain Associates with Mitral Regurgitation (MR) Severity and Cardiac Function in Primary and Secondary MR Patients”. In Proceedings: Society for Cardiovascular Magnetic Resonance (SCMR) 26th annual meeting, January 25-28, 2023 (Accepted)
- Siva Sreedhar, Teodora Chitiboi, Maurice Pradella, and Mohammed S.M. Elbaz, Bringing the Spotlight Back to Segmental Strain: Identifying Reproducible Segments for Left Ventricular Strain Evaluation. Society of Magnetic Resonance Angiography. Aug 23-26, 2022.
Awards
- American Heart Association (AHA) Student Scholarships in Cardiovascular Disease Award “Quantifying the reproducibility of 3D Left Atrial cardiac MRI strain measurements” Student: Siva Sreedhar; Advisor: Mohammed Elbaz, PhD
- Travel Award from Society of Magnetic Resonance Angiography (SMRA) Conference, 2022